In relation to infection, what does sepsis primarily affect?

Sepsis primarily affects the bloodstream, as it is a systemic response to infection that can lead to widespread inflammation throughout the body. When an infection occurs, pathogens enter the bloodstream, triggering the body's immune response. This response releases various inflammatory mediators that can cause blood vessel dilation, increased vascular permeability, and ultimately lead to organ dysfunction or failure if not promptly treated.

Sepsis can arise from infections in various locations in the body, such as the lungs, urinary tract, abdomen, or skin, but it is the presence of pathogens or their toxins in the bloodstream that defines the condition. When the infection spreads beyond its original site and into the bloodstream, it can lead to serious complications, including septic shock and death if not addressed quickly, making the bloodstream the primary target in the context of sepsis.